Product Description
alphaKlothoLR is a patented, long-release version of the recombinant Klotho protein, which contains specific amino acid sequences, linkers, and an albumin binding group that allows for a sustained delivery of Klotho with cellular activity up to 19 days.
This research-grade construct combines α-Klotho protein with a proprietary 29-amino acid albumin binding peptide (GGSGGSGGSGGRLIEDICLPRWGCLWEDD). The modification enables strong albumin binding affinity (<20 nM) while maintaining native FGF23 binding activity (15-30 nM).
Produced through recombinant expression with rigorous third-party testing. Each batch includes HPLC and LC-MS verification to confirm molecular identity and purity standards. Complete analytical documentation supports laboratory applications investigating protein-albumin interactions, FGF23 signaling pathways, and albumin binding mechanisms.
For in vitro research use only.
Klotho Protein Information
| Property | Value |
| Peptide Sequence | α-Klotho protein (1012 amino acids) + albumin binding construct: GGSGGSGGSGGRLIEDICLPRWGCLWEDD |
| Molecular Weight | ~133-135 kDa (full construct with albumin binder) |
| Albumin Binding Affinity (Kd) | <20 nM |
| FGF23 Binding Affinity (Kd) | 15-30 nM (optimized: 16.2 nM) |
| Synonyms | α-Klotho-albumin binding construct, Modified Klotho with glycine-serine linker |
Lyophilized Peptides:
These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.
